These projects were made possible from Cure Alzheimer's Fund support.
| Project Description | Researchers | Funding |
|---|---|---|
| Characterization of Tau Pathology Heterogeneity Across the Alzheimer’s Disease Spectrum |
2022, 2023 $402,500 |
These published papers resulted from Cure Alzheimer’s Fund support.
Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., ... Scheltens, P., ... Zetterberg, H., ... Bateman, R. J., ... Ossenkoppele, R., … Jansen, W. J. Associations of lifestyle factors with amyloid pathology in persons without dementia, Journal of Alzheimer's Disease, November 13, 2025, Read More
Mastenbroek, S. E., Collij, L. E., Anijärv, T. E., Rittmo, J., Young, A. L., Strandberg, O., Smith, R., Spotorno, N., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Parchi, P., Vogel, J. W., Barkhof, F., Ossenkoppele, R., & Hansson, O. Biological classification of memory clinic patients, Brain, October 29, 2025, Read More
Salvadó, G., Janelidze, S., Bali, D., Dolado, A. O., Therriault, J., … Petersen, R. C., Jack, C. R., Jr., Schindler, S. E., Suárez-Calvet, M., Ossenkoppele, R., Hansson, O., for the ADNI, ALFA, and PREVENT-AD Study Groups Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease, JAMA Neurology, September 15, 2025, Read More
Bocancea, D. I., van Loenhoud, A. C., Kuijper, B., Calandri, I. L., Groot, C., Venkatraghavan, V., de Boer, C., Ten Kate, M., Trieu, C., Teunissen, C. E., van de Giessen, E., Leeuwis, A. E., Schlueter, L. M., van Harten, A. C., Pijnenburg, Y. A. L., Barkhof, F., van der Flier, W. M., & Ossenkoppele, R. Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort, Brain Communications, September 6, 2025, Read More
Anijärv, T. E., Ossenkoppele, R., Smith, R., Pichet Binette, A., Collij, L. E., Behjat, H. H., Rittmo, J., Karlsson, L., Ahmadi, K., Strandberg, O., Alzheimer’s Disease Neuroimaging Initiative, van Westen, D., Vogel, J. W., Stomrud, E., Palmqvist, S., Mattsson-Carlgren, N., Spotorno, N., & Hansson, O. Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease, Nature Communications, September 5, 2025, Read More
de Bruin, H., Groot, C., Barthel, H., Bischof, G. N., … Hansson, O. … Ossenkoppele, R. Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease, Brain, August 14, 2025, Read More
Mastenbroek, S. E., Collij, L. E., Vogel, J. W., Caldera, S., Serrano, G. E., Adler, C. H., Vargiu, C. M., Palmqvist, S., Barkhof, F., Parchi, P., Beach, T. G., Ossenkoppele, R., & Hansson, O. Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification, Nature Communications, August 5, 2025, Read More
Singleton, E. H., Mattsson-Carlgren, N., Pichet Binette, A., Stomrud, E., Strandberg, O., Palmqvist, S., Ossenkoppele, R., & Hansson, O. Longitudinal tau aggregation, atrophy, and cognitive decline in Alzheimer’s diseas, Alzheimer's & Dementia, July 8, 2025, Read More
Carrigan, M., Bocancea, D. I., Vogel, J., van Loenhoud, A. C., Tesi, N., Barkhof, F., Lucassen, P. J., van der Flier, W. M., Krugers, H. J., Van der Lee, S. J., & Ossenkoppele, R. A novel approach to resilience and its links with education and Alzheimer’s disease genetics, Alzheimer's & Dementia, July 4, 2025, Read More
Janelidze, S., Collij, L. E., Mattsson-Carlgren, N., Antill, A., Laymon, C. M., Lott, I., Rosas, H. D., Minhas, D. S., Luo, W., Zaman, S., Alzheimer's Biomarker Consortium–Down Syndrome investigators, Mapstone, M., Head, E., Lai, F., Hartley, S. L., Ances, B. M., Krinsky-McHale, S. J., Lee, J. H., Ossenkoppele, R., Christian, B. T., … Hansson, O. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study, The Lancet Neurology, June 18, 2025, Read More
Moscoso, A., Heeman, F., Raghavan, S., Costoya-Sánchez, A., van Essen, M., ... Ossenkoppele, R., ...Hansson, O., ... Petersen, R. C., … PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity, JAMA, June 16, 2025, Read More
Coomans, E. M., van Tol, B., Groot, C., Smith, R., Palmqvist, S., Stomrud, E., Pontecorvo, M. J., Shcherbinin, S., Kennedy, I., Kotari, V., van der Flier, W. M., Pijnenburg, Y. A. L., Mattsson-Carlgren, N., Hansson, O., van de Giessen, E., & Ossenkoppele, R. Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [18F]flortaucipir imaging: TAU-SPEX, European Journal of Nuclear Medicine and Molecular Imaging, June 7, 2025, Read More
Pichet Binette, A., Smith, R., Salvadó, G., Tideman, P., Glans, I., van Westen, D., Groot, C., Ossenkoppele, R., Stomrud, E., Parchi, P., Zetterberg, H., Blennow, K., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., Hansson, O., & Alzheimer’s Disease Neuroimaging Initiative Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease, JAMA Neurology, May 19, 2025, Read More
Palmqvist, S., Warmenhoven, N., Anastasi, F., Pilotto, A., Janelidze, S., Tideman, P., Stomrud, E., Mattsson-Carlgren, N., Smith, R., Ossenkoppele, R., Tan, K., Dittrich, A., Skoog, I., Zetterberg, H., … Hansson, O. Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform, Nature Medicine, April 9, 2025, Read More
Horie, K., Salvadó, G., Koppisetti, R. K., Janelidze, S., Barthélemy, N. R., He, Y., Sato, C., Gordon, B. A., Jiang, H., Benzinger, T. L. S., Stomrud, E., Holtzman, D. M., Mattsson-Carlgren, N., Morris, J. C., Palmqvist, S., Ossenkoppele, R., Schindler, S. E., Hansson, O., & Bateman, R. J. Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease, Nature Medicine, March 31, 2025, Read More
Ossenkoppele, R., Salvadó, G., Janelidze, S., Pichet Binette, A., Bali, D., ... Bateman R. J., ... Petersen, R. C, Jack, C. R., Jr, & Hansson, O. Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials, Nature Aging, March 28, 2025, Read More
Kamps, S., Hempel, H. L., van Amerongen, S., de Bruin, H., van der Linden, F. H. C., Venkatraghavan, V., van der Flier, W. M., Pijnenburg, Y. A. L., Barkhof, F., Scheltens, P., Ossenkoppele, R., & Vijverberg, E. G. B. Enlarged cavum septum pellucidum as a neuroimaging signature of head impact exposure, Brain Communications, February 21, 2025, Read More
Oomens, J. E., van Gils, V., Vos, S. J. B., Freeze, W. M., Maserejian, N. N., ... Zetterberg, H., ... Ossenkoppele, R., … BIOFACE Study Group Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study, JAMA Network Open, January 22, 2025, Read More
Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., & Ossenkoppele, R. Biological mechanisms of resilience to tau pathology in Alzheimer’s disease, Alzheimer's Research & Therapy, October 12, 2024, Read More
Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease, Nature Communications, September 14, 2024, Read More
Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G., & Hansson, O. Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care, JAMA, July 28, 2024, Read More
Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., … Petersen, R. C., ... Ossenkoppele, R., ... Hansson, O., ... Doré, V. Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model, Alzheimer's & Dementia, July 23. 2024, Read More
Soleimani-Meigooni, D. N., Smith, R., Provost, K., Lesman-Segev, O. H., Allen, I. E., Chen, M. K., Cho, H., Edwards, L., Janelidze, S., La Joie, R., Mundada, N., Ossenkoppele, R., Stomrud, E., Strandberg, O., Strom, A., Boxer, A. L., Dage, J. L., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., …, Hansson, O., Rabinovici, G. D. Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study, Annals of Neurology, June 18, 2024, Read More
Mastenbroek, S. E., Vogel, J. W., Collij, L. E., Serrano, G. E., Tremblay, C., Young, A. L., Arce, R. A., Shill, H. A., Driver-Dunckley, E. D., Mehta, S. H., Belden, C. M., Atri, A., Choudhury, P., Barkhof, F., Adler, C. H., Ossenkoppele, R., Beach, T. G., & Hansson, O. Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology, Nature Communications, June 15, 2024, Read More
Groot, C., Smith, R., Collij, L. E., Mastenbroek, S. E., Stomrud, E., Binette, A. P., Leuzy, A., Palmqvist, S., Mattsson-Carlgren, N., Strandberg, O., Cho, H., Lyoo, C. H., Frisoni, G. B., Peretti, D. E., Garibotto, V., La Joie, R., Soleimani-Meigooni, D. N., Rabinovici, G., Ossenkoppele, R., & Hansson, O. Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment, JAMA Neurology, June 10, 2024, Read More
Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More
Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine, February 21, 2024, Read More
Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain, May 8, 2023, Read More
Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain, September 18, 2023, Read More
Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain, March 27, 2023, Read More
Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology, October 14, 2023, Read More
Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More
Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S., & Hansson, O. Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies, JAMA Neurology, December 4, 2023, Read More