Modulation of Abeta Assembly and Cytotoxicity by a Fragment of Myelin Basic Protein
Researchers:
Funding year(s):
2008
Funding to date:
$100,000
We have identified myelin basic protein (MBP) as a novel factor in brain that can bind A-beta and potently inhibit its assembly into fibrils. In light of this novel finding the overall hypothesis of this proposal is that defined fragments of MBP can regulate A-beta assembly and modulate its cytotoxic properties. This will provide the basis for developing novel and potent A-beta assembly inhibitors.
