These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Oligomer Collaborative Projects |
2006 $1,550,000 |
|
Passive Tau Immunotherapy |
2010 $100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Guo, J. L., & Lee, V. M. Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, Journal of Biological Chemistry, March 3, 2011, Read More
Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., & Holtzman, D. M. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, Journal of Neuroscience, September 14, 2011, Read More
Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M. Tau pathology spreads in S19 tau transgenic mice following locus coeruleus (LC) injections of synthestic tau fibrils is determined by the LC’s afferent and efferent connections, Acta Neuropathologica, July 7, 2015, Read More
Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., & Lee, V. M. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzhiemer’s like tauopathy, Journal of Neuroscience, January 16, 2013, Read More
Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain, May 8, 2023, Read More
Leyns, C. E. G., Gratuze, M., Narasimhan, S., Jain, N., Koscal, L. J., Jiang, H., Manis, M., Colonna, M., Lee, V. M. Y., Ulrich, J. D., & Holtzman, D. M. TREM2 Function Impedes Tau Seeding in Neuritic Plaques, Nature Neuroscience, June 1, 2019, Read More