Saha, P., & Sisodia, S. S. Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer’s disease, Neurotherapeutics, July 24, 2024, Read More

Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., Parhizkar, S., Zhang, X., Laury, M. L., Mondal, P., Gomm, A., Schipma, M. J., Mallah, D., Butovsky, O., Chang, E. B., Tanzi, R. E., Gilbert, J. A., Holtzman, D. M. & Sisodia, S. S. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner, Molecular Neurodegeneration, February 17, 2024, Read More

Zhang, X., Hoey, R. J., Lin, G., Koide, A., Leung, B., Ahn, K., Dolios, G., Paduch, M., Ikeuchi, T., Wang, R., Li, Y. M., Koide, S., & Sisodia, S. S. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of gamma-secrtase using synthetic antibodies, Proceedings of the National Academy of Sciences of the United States of America, May 14, 2012, Read More

Zhang, X., Sullivan, E., Scimeca, M., Wu, X., Li, Y. M., & Sisodia, S. S. Evidence that the “Lid” domain of nicastrin is not essential for regulating secretase activity, Journal of Biological Chemistry, February 17, 2016, Read More

Zhang, X., Hoey, R., Koide, A., Dolios, G., Paduch, M., Nguyen, P., Wu, X., Li, Y., Wagner, S. L., Wang, R., Koide, S., & Sisodia, S. S. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of gamma-secretase, Journal of Biological Chemistry, October 28, 2014, Read More

Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. Regulation of hippocampal progenitor cell survival, proliferation, and dendritic development by BDNF, Molecular Neurodegeneration, December 21, 2009, Read More

Meier, M., Kennedy-Darling, J., Choi, S. H., Norstrom, E. M., Sisodia, S. S., & Ismagilov, R. F. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides, Angewandte Chemie (International ed. in English), January 30, 2009, Read More

Choi, S. H., Veeraraghavalu, K., Lazarov, O., Marler, S., Ransohoff, R. M., Ramirez, J. M., & Sisodia, S. S. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation, Neuron, August 28, 2008, Read More

Ahn, K., Shelton, C. C., Tian, Y., Zhang, X., Gilchrist, M. L., Sisodia, S. S., & Li, Y. M. Activation and intrinsic gamma-secretase activity of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America, November 29, 2010, Read More

Dodiya, H. B., Frith, M., Sidebottom, A., Cao, Y., Koval, J., Chang, E., & Sisodia, S. S. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice, Scientific Reports, May 18, 2020, Read More

Veetil, A. T., Zou, J., Henderson, K. W., Jani, M. S., Shaik, S. M., Sisodia, S. S., Hale, M. E., & Krishnan, Y. DNA-based fluorescent probes of NOS2 activity in live brains, Proceedings of the National Academy of Sciences of the United States of America, June 17, 2020, Read More

Veeraraghavalu, K., & Sisodia, S. S. Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells., Proceedings of the National Academy of Sciences of the United States of America, May 14, 2013, Read More

Shaik, S. M., Cao, Y., Gogola, J. V., Dodiya, H. B., Zhang, X., Boutej, H., Han, W., Kriz, J., & Sisodia, S. S. Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome, Molecular Neurodegeneration, December 16, 2023, Read More

Brunholz, S., Sisodia, S., Lorenzo, A., Deyts, C., Kins, S., & Morfini, G. Axonal Transport of APP and the spatial regulation of APP cleavage and function in neuronal cells, Experimental Brain Research, September 30, 2011, Read More

Main, B. S., & Minter, M. R. Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, March 23, 2017, Read More

Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone neuronal progenitors via cell-autonomous mechanisms involving Notch signaling, Journal of Neuroscience, May 19, 2010, Read More

Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K., & Sisodia, S. S. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2, Journal of Neuroscience, June 20, 2012, Read More

DeBoer, S. R., Dolios, G., Wang, R., & Sisodia, S. S. Differential release of ss-Amyloid from Dendrite versus Axon-targeted APP, Journal of Neuroscience, September 14, 2014, Read More

Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation, and survival of adult hippocampal progenitors., Molecular Neurodegeneration, October 20, 2013, Read More

Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A. C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., Thunemann, M., Feil, R., Sisodia, S. S., Skodras, A., & Jucker, M. Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single cell imaging, Nature Neuroscience, August 28, 2017, Read More

Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. Heterogeneity of CNS Myeloid Cells and their roles in Neurodegeneration, Nature Neuroscience, September 27, 2011, Read More

Veetil, A. T., Chakraborty, K., Xiao, K., Minter, M. R., Sisodia, S. S., & Krishnan, Y. Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules, Nature Nanotechnology, August 21, 2017, Read More

Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 12/27/2009, Read More

Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., & Sisodia, S. S. Sex-specific effects of microbiome perturbations on cerebral amyloid beta amyloidosis and microglia phenotypes, Journal of Experimental Medicine, May 16, 2019, Read More

Saha, P., Weigle, I. Q., Slimmon, N., Poli, P. B., Patel, P., Zhang, X., Cao, Y., Michalkiewicz, J., Gomm, A., Zhang, C., Tanzi, R. E., Dylla, N., Al-Hendy, A., & Sisodia, S. S. Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function, Scientific Reports, January 21, 2024, Read More

Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health, April 22, 2022, Read More

Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., Xia, J., Olszewski, M., Zhang, X., Schipma, M. J., Chang, E. B., Tanzi, R. E., Gilbert, J. A., & Sisodia, S. S. Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia, Journal of Experimental Medicine, January 3, 2022, Read More

Zhang, X., Zhang, C. M., Prokopenko, D., Liang, Y., Zhen, S. Y., Weigle, I. Q., Han, W., Aryal, M., Tanzi, R. E., & Sisodia, S. S. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo, Journal of Experimental Medicine, June 7, 2021, Read More

Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., & Tanzi, R. E. Alternatives to Amyloid for Alzheimer’s Disease Therapies-A Symposium Report, Annals of the New York Academy of Sciences, May 29, 2020, Read More

Zhang, X., Zhang, C., Prokopenko, D., Liang, Y., Han, W., Tanzi, R. E., & Sisodia, S. S. Negative evidence for a role of APH1B T27I variant in Alzheimer’s disease, Human Molecular Genetics, April 15, 2020, Read More

Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., Jabri, B., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease, Scientific Reports, September 5, 2017, Read More

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. Antibiotic-induced perturbation in gut microbial diversity influences neuro-inflammation and amylodiosis in a murine model of Alzheimer’s disease, Scientific Reports, July 16, 2016, Read More

Veeraraghavalu, K., Zhang, C., Zhang, X., Tanzi, R. E., & Sisodia, S. S. Age-dependent, non-cell autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons, Journal of Neuroscience, March 5, 2014, Read More

Wagner, S. L., Zhang, C., Cheng, S., Nguyen, P., Zhang, X., Rynearson, K. D., Wang, R., Li, Y., Sisodia, S. S., Mobley, W. C., & Tanzi, R. E. Soluble gamma-secretase modulators slectively inhibit the production of the 42 amino-acid amyloid beta peptide variant and augment the production of multiple carboxy-truncated amyloid beta species, Biochemistry, January 22, 2014, Read More