Sangram S. Sisodia, Ph.D.

Thomas Reynolds Sr. Family Professor of Neurosciences; Professor, Departments of Neurobiology and Neurology; Director, Center for Molecular Neurobiology, University of Chicago

Dr. Sisodia is a leading expert on the molecular and cell biology of Alzheimer’s disease pathology. He has been at the forefront of learning how the familial Alzheimer’s disease (FAD) genes, including the amyloid precursor protein and the presenilins, function normally, and contribute to Alzheimer’s disease pathogenesis. Most recently, Dr. Sisodia’s studies have shown that in mice, exercise has a remarkable ability to protect against Alzheimer’s disease pathology by favorably changing gene activity in the brain.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Identifying the Sex-Specific Roles of the Gut Microbiome-Brain Axis in a Mouse Model of Amyloid Beta Amyloidosis 2022


Temporal Relationships Between Gut Dysbiosis and Microglia Cell Activation Following Antibiotic Treatment 2022


Effect of Gut Microbiome Dysbiosis on Neuroinflammation and Amyloid Beta Deposition: A Longitudinal Micro-PET Study in Alzheimer’s Transgenic Mice 2020


Mechanisms By Which the Gut Microbiome Influences Amyloid Deposition and Neuroinflammation in the APPswe/ PS1DE9 Mouse Model of Amyloid Beta Amyloidosis 2017


Mechanisms By Which the Gut Microbiome Influences Amyloid Deposition and Neuroinflammation in Mouse Models of Alzheimer’s Disease 2016


In Vitro and In Vivo Analysis of APP Variants 2016, 2017, 2019


The Role of Microbial Immune Responses in Alzheimer’s Disease 2015


Investigations of the Mechanism of Action of TagretinR/Bexarotene on Amyloid Clearance in Transgenic Mouse Models 2012


Oligomer Collaborative Projects 2006


Molecular Mechanism Underlying Hippocampal Neurogenisis by Familial AD-linked Presenilin-1 Variants 2008


Modulation of Abeta Deposition by Cell-Specific Mechanisms 2010, 2011


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging, Nature Neuroscience, 20(10), Oct 2017, 1371-1376, Read More

Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer’s disease, Scientific Reports, 7, 5 Sep 2017, Read More

Bevan S. Main, Myles R. Minter Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11, 23 Mar 2017, 151, Read More

Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li and Sangram S. Sisodia Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity, Journal of Biological Chemistry, 291(13), 25 Mar 2016, 6748-53, Read More

Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10), 5 March 2014, 3668-3673, Read More

Xulun Zhang1, Krassimira Garbett2, Karthikeyan Veeraraghavalu, Brian Wilburn, Reid Gilmore, Karoly Mirnics, and Sangram S. Sisodia A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2, The Journal of Neuroscience, 32(25), June 20, 2012, 8633-8648, Read More

Prinz M, Priller J, Sisodia SS, Ransohoff RM Heterogeneity of CNS myeloid cells and their roles in neurodegeneration, Nat Neurosci., 14(10), 2011 Sept 27, 1227-35, Read More

Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li Activation and Intrinsic γ-Secretase Activity of Presenilin 1, Proc. Natl. Acad. Sci USA, 50, Oct 15, 2010, 21435–21440, Read More

Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling, The Journal of Neuroscience, 30(20), May 19, 2010, 6903-6915, Read More

Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13(2), Feb 2010, 190-196, Read More

Choi SH, Li Y, Parada LF, Sisodia SS Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52, Read More

Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489, Read More

Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580, Read More

Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 6/27/2007, 7006-7010, Read More