These projects were made possible from Cure Alzheimer's Fund support.
These published papers resulted from Cure Alzheimer’s Fund support.
Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging, Nature Neuroscience, 20(10), Oct 2017, 1371-1376, Read More
Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer’s disease, Scientific Reports, 7, 5 Sep 2017, Read More
Bevan S. Main, Myles R. Minter Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11, 23 Mar 2017, 151, Read More
Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li and Sangram S. Sisodia Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity, Journal of Biological Chemistry, 291(13), 25 Mar 2016, 6748-53, Read More
Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10), 5 March 2014, 3668-3673, Read More
Xulun Zhang1, Krassimira Garbett2, Karthikeyan Veeraraghavalu, Brian Wilburn, Reid Gilmore, Karoly Mirnics, and Sangram S. Sisodia A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2, The Journal of Neuroscience, 32(25), June 20, 2012, 8633-8648, Read More
Prinz M, Priller J, Sisodia SS, Ransohoff RM Heterogeneity of CNS myeloid cells and their roles in neurodegeneration, Nat Neurosci., 14(10), 2011 Sept 27, 1227-35, Read More
Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li Activation and Intrinsic γ-Secretase Activity of Presenilin 1, Proc. Natl. Acad. Sci USA, 50, Oct 15, 2010, 21435–21440, Read More
Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling, The Journal of Neuroscience, 30(20), May 19, 2010, 6903-6915, Read More
Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13(2), Feb 2010, 190-196, Read More
Choi SH, Li Y, Parada LF, Sisodia SS Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52, Read More
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489, Read More
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580, Read More
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 6/27/2007, 7006-7010, Read More