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Discovery of CK1 Activators for Inducing the Autophagic Degradation of APP Beta-CTF

Funding year(s): 
2015 to 2016
Funding to date: 

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 5 million people in the United States. One of the hallmarks of AD is the accumulation of amyloid plaques in the brain of patients. The amyloid plaque is composed of beta amyloid (Abeta) peptide, which originates from an amyloid precursor protein (APP).

Multiple lines of evidence suggest that a defective clearance mechanism is involved in the pathogenesis of Alzheimer’s disease. Our laboratory has discovered a novel molecular pathway regulating protein clearance, which represents an attractive therapeutic target for developing drugs for Alzheimer’s disease. This project represents a direct effort to search for small molecule compounds that can restore protein clearance.