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Pathway Cross-talks Associated with Sex and Risk for Alzheimer’s Disease

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Some recent findings suggest that women with mild cognitive impairment may progress to Alzheimer’s disease (AD) at faster rates than men. However, the biological basis of the sex differences in AD still is debated and warrants a more detailed examination. We propose to use novel “big data” computational methodologies to discover how cross-talk between biological pathways may be linked to sex differences and cognitive decline in people at risk for Alzheimer’s.